What are fair tests of treatments?
Not all is created equal: some tests of s are more reliable than others. Sometimes tests of treatments can be […]
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What can be done to improve tests of treatments?
We can all play a part in ensuring that treatment decisions are based on fair tests of treatments. This will […]
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Linguistic strategies for improving informed consent in clinical trials among low health literacy patients
Evidence-based guidance on how to improve informed consent processes for patients being invited to participate in clinical research.
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Informed Health Choices Podcasts
Each episode includes a short story with an example of a treatment claim and a simple explanation of a Key Concept used to assess that claim
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Know Your Chances
This book has been shown in two randomized trials to improve peoples' understanding of risk in the context of health care choices.
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Evidence for everyday health choices
A 17-min slide cast by Lynda Ware, on the history of EBM, what Cochrane is, and how to understand the real evidence behind the headlines.
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Sunn Skepsis
Denne portalen er ment å gi deg som pasient råd om kvalitetskriterier for helseinformasjon og tilgang til forskningsbasert informasjon.
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Dancing statistics: Explaining variance
A 5-minute film demonstrating the statistical concept of variance through dance.
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Dancing statistics: sampling & standard error
A 5-minute film demonstrating the statistical concept of sampling and standard error through dance.
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Julia Belluz – Lessons from the trenches of evidence-based health journalism at Vox.com
20-minute talk by Julia Belluz on the need to bring the cultures of health journalism and EBM together.
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Don’t jump to conclusions, #Ask for Evidence
An introduction to the ‘Ask for Evidence’ initiative launched by ‘Sense about Science’ in 2016.
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The surrogate battle – is lower always better?
James McCormick recruits a furious Fuhrer to point out that taking drugs to lower surrogate measures of ill health is a confidence trick.
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Tom Hanks and Type 2 Diabetes
A 50-minute illustrated talk by James McCormack prompted by Tom Hanks’ announcement that he had been diagnosed with Type 2 diabetes.
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Bohemian Polypharmacy
James McCormack recruits help from Queen to warn of the dangers of ‘Bohemian Polypharmacy’ in music.
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Choosing Wisely
James McCormack using song and dance to warn about the negative effects of overtreatment.
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Like a bridge overdiagnosis
James McCormack with another of his brilliant parodies, warning about the dangers of becoming inappropriately labelled as ill.
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Reporting the findings: Absolute vs relative risk
Absolute Differences between the effects of two treatments matter more to most people than Relative Differences.
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Explaining the mission of the AllTrials Campaign (TED talk)
Half the clinical trials of medicines we use haven’t been published. Síle Lane shows how the AllTrials Campaign is addressing this scandal.
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Fish oil in the Observer: the return of a $2bn friend
Ben Goldacre draws attention to people’s wish to believe that a pill can be the solution to a complicated problem.
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Building evidence into education
Ben Goldacre explains why appropriate infrastructure is need to do clinical trials of sufficient rigour and size to yield reliable results.
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Anecdotes are great – if they convey data accurately
Ben Goldacre gives examples of how conclusions based on anecdotes and biased research can be damagingly misleading.
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Studies of studies show that we get things wrong
Ben Goldacre gives examples of how conclusions based on anecdotes and biased research can be damagingly misleading.
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Dodgy academic PR
Ben Goldacre: 58% of all press releases by academic institutions lacked relevant cautions and caveats about the methods and results reported
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All bow before the mighty power of the nocebo effect
Ben Goldacre discusses nocebo effects, through which unpleasant symptoms are induced by negative expectations, despite no physical cause.
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How do you regulate Wu?
Ben Goldacre finds that students of Chinese medicine are taught (on a science degree) that the spleen is “the root of post-heaven essence”.
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Science is about embracing your knockers
Ben Goldacre: “I don’t trust claims without evidence, especially not unlikely ones about a magic cream that makes your breasts expand.”
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NMT are suing Dr Wilmshurst. So how trustworthy are this company? Let’s look at their website…
Ben Goldacre celebrates Peter Wilmshurst, the doctor who blew the whistle on research misconduct in a study to which he was a contributor.
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Over there! An 8 mile high distraction made of posh chocolate!
Ben Goldcare illustrates strategies used by vested interests to discredit research with ‘inconvenient’ results.
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Brain imaging studies report more positive findings than their numbers can support. This is fishy.
Ben Goldacre explores how twice as many positive findings as could realistically have been expected from the data reported may have occurred
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What if academics were as dumb as quacks with statistics?
Ben Goldacre introduces a statistical error that appears in about half of all the published papers in academic neuroscience research.
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The strange case of the magnetic wine
Ben Goldacre shows how claims for the wine-maturing effects of magnets could be assessed with 50 people in an evening.
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Screen test
Ben Goldacre notes that even if people realize that screening programmes have downsides, people don’t regret being screened.
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Sampling error, the unspoken issue behind small number changes in the news
Ben Goldacre stresses the importance of taking account of “sampling variability” and confidence intervals.
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The certainty of chance
Ben Goldacre reminds readers how associations may simply reflect the play of chance, and describes Deming’s illustration of this.
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Publish or be damned
Ben Goldacre points out the indefensible practice of announcing conclusions from research studies which haven’t been published.
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How myths are made
Ben Goldacre draws attention to Steven Greenberg’s forensically based illustration of citation biases.
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Foreign substances in your precious bodily fluids
Ben Goldacre points out that there is no evidence giving strong support either to water fluoridationists or to anti-fluoridationists.
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Is it okay to ignore results from people you don’t trust?
Ben Goldacre: why it’s important to consider vested interests when judging research, but not to dismiss research by people you don’t like.
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Cherry picking is bad. At least warn us when you do it.
Ben Goldacre illustrates how biased ‘cherry picking’ and choosing from the relevant evidence can result in unreliable conclusions.
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Why won’t Professor Susan Greenfield publish this theory in a scientific journal?
Ben Goldacre challenges senior Oxford professor to publish the evidence supporting her claim that computer games cause dementia in children.
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Weasels Are on the Loose
Weaseling is the use of certain words to weaken a claim, so that the author can say something without actually saying it and avoid criticism
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Introduction to Evidence-Based Medicine
Bill Caley’s 26 slides with notes used as an ‘Introduction to Evidence-Based Medicine’.
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The power of the placebo effect
Emma Bryce’s video presents information about placebo effects: treatments not supposed to have an effect but which make people feel better.
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Not all scientific studies are created equally
David Schwartz dissects two types of studies that scientists use, illuminating why you should always approach claims with a critical eye.
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Taking account of the play of chance
Differences in outcome events in treatment comparisons may reflect only the play of chance. Increased numbers of events reduces this problem
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Quantifying uncertainty in treatment comparisons
Small studies in which few outcome events occur are usually not informative and the results are sometimes seriously misleading.
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Bringing it all together for the benefit of patients and the public
Improving reports of research and up-to-date systematic reviews of reliable studies are essential foundations of effective health care.
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Tipsheet for reporting on drugs, devices and medical technologies
Questions that will be familiar to reporters covering health and medicine.
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Tips for understanding Intention-to-Treat analysis
Ignoring non-compliance with assigned treatments leads to biased estimates of treatment effects. ITT analysis reduces these biases.
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Tips for understanding Absolute vs. Relative Risk
Absolute Differences between the effects of two treatments matter more to most people than Relative Differences.
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Tips for understanding Non-inferiority Trials
A non-inferiority experiment endeavours to show that a new intervention is ‘not unacceptably worse’ than the comparison intervention.
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Cyagen is paying for citations
Pharmaceutical company Cyagen offers researchers and other writers $100 or more for citing their products in publications.
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GenerationR – The importance of involving children and young people in research
3/3, 22-min video at the launch of GenerationR, a network of young people who advise researchers.
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Generation R – The need to reduce waste in clinical research involving children
1/3, 14-min video at the launch of GenerationR, a network of young people who advise researchers.
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Making sense of randomized trials
A description of how clinical trials are constructed and analysed to ensure they provide fair comparisons of treatments.
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Common Sources of Bias
Bias (the conscious or unconscious influencing of a study and its results) can occur in different ways and renders studies less dependable.
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5 reasons why you might not get the best healthcare
Five reasons why patients may not always get the best care available.
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Tamiflu: securing access to medical research data
A campaign by researchers has shown that Roche spun the research on Tamiflu to meet their commercial ends.
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MMR: the facts in the case of Dr Andrew Wakefield
This 15-page cartoon explains the events surrounding the MMR controversy, and provides links to the relevant evidence.
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Los intervalos de confianza en investigación
¿Para qué sirven los intervalos de confianza en los estudios de investigación?
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Toma de Decisiones Compartidas
¿Por qué nosotros, los pacientes, debemos participar en la toma de decisiones médicas importantes?
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The need to compare like-with-like in treatment comparisons
Allocation bias results when trials fail to ensure that, apart from the treatments being compared, ‘like will be compared with like'.
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Why avoiding differences between treatments allocated and treatments received is important
Knowledge of which treatments have been received by which study participants can affect adherence to assigned treatments and result in bias.
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The need to avoid differences in the way treatment outcomes are assessed
Biased treatment outcome assessment can result if people know which participants have received which treatments.
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Avoiding biased selection from the available evidence
Systematic reviews are used to identify, evaluate and summarize all the evidence relevant to addressing a particular question.
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Preparing and maintaining systematic reviews of all the relevant evidence
Unbiased, up-to-date systematic reviews of all the relevant, reliable evidence are needed to inform practice and policy.
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Dealing with biased reporting of the available evidence
Biased reporting of research occurs when the direction or statistical significance of results influences how research is reported.
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Using the results of up-to-date systematic reviews of research
Trustworthy evidence from research is necessary, but not sufficient, to improve the quality of health care.
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Why treatment comparisons must be fair
Fair treatment comparisons avoid biases and reduce the effects of the play of chance.
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Introduction to JLL Explanatory Essays
Professionals sometimes harm patients by using inadequately evaluated treatments. Research addressing uncertainties can reduce this harm.
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Avoiding biased treatment comparisons
Biases in tests of treatments are those factors that can lead to conclusions that are systematically different from the truth.
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Bias introduced after looking at study results
Biases can be introduced when knowledge of the results of studies influences analysis and reporting decisions.
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Reducing biases in judging unanticipated effects of treatments
As with anticipated effects of treatments, biases and the play of chance must be reduced in assessing suspected unanticipated effects.
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Recognizing researcher/sponsor biases and fraud
The vested interests of researchers and organizations tend to be reflected in reports of treatment research in which they are involved.
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Video games and health improvement: a literature review of randomized controlled trials
This is a critical appraisal of a non-systematic review of randomized trials of video games for improving health.
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Why comparisons must address genuine uncertainties
Too much research is done when there are no genuine uncertainties about treatment effects. This is unethical, unscientific, and wasteful.
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Surrogate markers may not tell the whole story
A webpage explaining the limitations of using surrogate outcome markers in clinical research.
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Why treatment comparisons are essential
Formal comparisons are required to assess treatment effects and to take account of the natural course of health problems.
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Why treatment uncertainties should be addressed
Ignoring uncertainties about the effects of treatments has led to avoidable suffering and deaths.
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Motivational Deficiency Disorder – a satirical look at disease mongering
Ray Moynihan’s 4-min video on ‘Motivational Deficiency Disorder’, illustrating ‘disease-mongering’.
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Making Sense of Screening
Screening tests can cause harm. This guide helps you to make sense of claims about screening for health conditions.
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What are systematic reviews?
A 3-min video by Jack Nunn and The Cochrane Consumers and Communication group for people unfamiliar with the concept of systematic reviews.
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Interactive PowerPoint Presentation about Clinical Trials
An interactive Powerpoint presentation for people thinking about participating in a clinical trial or interested in learning about them.
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Testing Treatments
Testing Treatments is a book to help the public understand why fair tests of treatments are needed, what they are, and how to use them.
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Annals Graphic Medicine: How screening is portrayed in the media
A cartoon series addressing the theme "Earlier is not necessarily better".
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Effectiveness Delusions
Cherry picking the results of people in sub-groups can be misleading.
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Cecil and those pellets again…
If possible, participants in clinical trials should not know which treatment they are receiving.
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Catch 22 – clinical trials edition
Fair comparisons of treatments in animals or highly selected groups of people may not be relevant.
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House Calls Please
Beware reliance on 'experience' without reference to relevant evidence.
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Composite Outcomes
Fair comparisons of treatments should measure important outcomes and avoid dependence on surrogate outcome measures.
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Biomarkers unlimited
Fair comparisons of treatments should measure important outcomes and avoid dependence on surrogate outcome measures.
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Department of Epidemiology
Presenting relative measures of treatment effects without presenting absolute measures can be misleading.
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Goldilocks
Cartoon and blog about how poorly performed systematic reviews and meta-analyses may misrepresent the truth.
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House of tottering cards
Poorly performed systematic reviews and meta-analyses may misrepresent the truth.
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Cherry Picking
Cherry-picking results that only support your own conclusion may mean ignoring important evidence that refutes a treatment claim.
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Secret life of trials
The results of single comparisons of treatments can be misleading.
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Desert Island Medical Journal
Small studies with few outcome events are usually not informative and can be misleading.
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Forest Plot Trilogy
Synthesising the results of similar but separate fair comparisons (meta-analysis) may help by yielding statistically more reliable estimates
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Significant Others
Statistical significance does not always mean meaningful or practical significance.
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False Precision
The use of p-values to indicate the probability of something occurring by chance may be misleading.
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Personal “No Worse”
People with vested interests may use misleading statistics to support claims about the effects of new treatments.
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Lisa luxuriant hair
If possible, participants in clinical trials should not know which treatment they are receiving.
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Suzie in despair
Apart from the treatments being compared, the comparison groups need to be similar.
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World without bias
Overcoming biases is difficult but important. Treatment comparisons must be fair.
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Avoid despair about biases
People who choose to ignore biases may do themselves and others harm.
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Does it work?
People with vested interests may use misleading statistics to support claims about the efects of new treatments.
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Thousand dollar placebo
People with vested interests may take advantage of peoples' fears or hopes..
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Promising treatments
'Promising' treatments greatly outnumber actual advances in treatment.
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Right to remain anxious
Earlier testing is not always better, and can lead to overdiagnosis, overtreatment and anxiety.
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De-awareness day
Earlier testing is not always better, and can lead to overdiagnosis and overtreatment.
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Alicia
Earlier testing is not always better, and can lead to overdiagnosis and overtreatment.
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Peer-Review
Even quality control steps, such as peer-review, can be affected by conflicts of interest.
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Gertrud
Exaggeration and hopes or fears can lead to unrealistic expectations about treatment effects.
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